Ontology highlight
ABSTRACT:
SUBMITTER: Yoon CH
PROVIDER: S-EPMC2683089 | biostudies-other | 2009 May
REPOSITORIES: biostudies-other
Yoon Cheol-Hee CH Lee Eun-Soo ES Lim Dae-Seog DS Bae Yong-Soo YS
Proceedings of the National Academy of Sciences of the United States of America 20090424 19
Type I IFN-induced expression of dsRNA-activated protein kinase (PKR) during viral infection is a well-established antiviral mechanism. However, little is known about the expression of PKR in the context of p53 and about PKR involvement in p53-mediated tumor suppression. Here, we report that PKR is a p53 target gene and plays an important role in the tumor-suppressor function of p53. Activation of p53 by genotoxic stress induces a significant level of PKR expression by acting on the newly identi ...[more]