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Nature's lab for derivatization: new and revised structures of a variety of streptophenazines produced by a sponge-derived Streptomyces strain.

ABSTRACT: Eight streptophenazines (A-H) have been identified so far as products of Streptomyces strain HB202, which was isolated from the sponge Halichondria panicea from the Baltic Sea. The variation of bioactivities based on small structural changes initiated further studies on new derivatives. Three new streptophenazines (I-K) were identified after fermentation in the present study. In addition, revised molecular structures of streptophenazines C, D, F and H are proposed. Streptophenazines G and K exhibited moderate antibacterial activity against the facultative pathogenic bacterium Staphylococcus epidermidis and against Bacillus subtilis. All tested compounds (streptophenazines G, I-K) also showed moderate activities against PDE 4B.

SUBMITTER: Kunz AL

PROVIDER: S-EPMC4012441 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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Nature's lab for derivatization: new and revised structures of a variety of streptophenazines produced by a sponge-derived Streptomyces strain.

Kunz Anna Lena AL Labes Antje A Wiese Jutta J Bruhn Torsten T Bringmann Gerhard G Imhoff Johannes F JF

Marine drugs 20140325 4

Eight streptophenazines (A-H) have been identified so far as products of Streptomyces strain HB202, which was isolated from the sponge Halichondria panicea from the Baltic Sea. The variation of bioactivities based on small structural changes initiated further studies on new derivatives. Three new streptophenazines (I-K) were identified after fermentation in the present study. In addition, revised molecular structures of streptophenazines C, D, F and H are proposed. Streptophenazines G and K exhi ...[more]

PMID: 24670532

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