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Chronic wasting disease agents in nonhuman primates.


ABSTRACT: Chronic wasting disease is a prion disease of cervids. Assessment of its zoonotic potential is critical. To evaluate primate susceptibility, we tested monkeys from 2 genera. We found that 100% of intracerebrally inoculated and 92% of orally inoculated squirrel monkeys were susceptible, but cynomolgus macaques were not, suggesting possible low risk for humans.

SUBMITTER: Race B 

PROVIDER: S-EPMC4012792 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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Chronic wasting disease agents in nonhuman primates.

Race Brent B   Meade-White Kimberly D KD   Phillips Katie K   Striebel James J   Race Richard R   Chesebro Bruce B  

Emerging infectious diseases 20140501 5


Chronic wasting disease is a prion disease of cervids. Assessment of its zoonotic potential is critical. To evaluate primate susceptibility, we tested monkeys from 2 genera. We found that 100% of intracerebrally inoculated and 92% of orally inoculated squirrel monkeys were susceptible, but cynomolgus macaques were not, suggesting possible low risk for humans. ...[more]

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