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PCR for detection of oseltamivir resistance mutation in influenza A(H7N9) virus.


ABSTRACT: Sensitive molecular techniques are needed for rapid detection of the R292K oseltamivir-resistant mutant of influenza A(H7/N9) virus strain to monitor its transmission and guide antiviral treatment. We developed a real-time reverse transcription PCR and single nucleotide polymorphism probes to differentiate this mutant strain in mixed virus populations in human specimens.

SUBMITTER: Wang W 

PROVIDER: S-EPMC4012804 | biostudies-literature |

REPOSITORIES: biostudies-literature

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