Ontology highlight
ABSTRACT:
SUBMITTER: Morgan JL
PROVIDER: S-EPMC4013215 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20140406 5
The bacterial signaling molecule cyclic di-GMP (c-di-GMP) stimulates the synthesis of bacterial cellulose, which is frequently found in biofilms. Bacterial cellulose is synthesized and translocated across the inner membrane by a complex of cellulose synthase BcsA and BcsB subunits. Here we present crystal structures of the c-di-GMP-activated BcsA-BcsB complex. The structures reveal that c-di-GMP releases an autoinhibited state of the enzyme by breaking a salt bridge that otherwise tethers a cons ...[more]