Ontology highlight
ABSTRACT:
SUBMITTER: Dubey BN
PROVIDER: S-EPMC6969517 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Dubey Badri N BN Agustoni Elia E Böhm Raphael R Kaczmarczyk Andreas A Mangia Francesca F von Arx Christoph C Jenal Urs U Hiller Sebastian S Plaza-Menacho Iván I Schirmer Tilman T
Proceedings of the National Academy of Sciences of the United States of America 20191227 2
Cytosolic hybrid histidine kinases (HHKs) constitute major signaling nodes that control various biological processes, but their input signals and how these are processed are largely unknown. In <i>Caulobacter crescentus</i>, the HHK ShkA is essential for accurate timing of the G1-S cell cycle transition and is regulated by the corresponding increase in the level of the second messenger c-di-GMP. Here, we use a combination of X-ray crystallography, NMR spectroscopy, functional analyses, and kinet ...[more]