Protein folding, protein homeostasis, and cancer.
Ontology highlight
ABSTRACT:
SUBMITTER: Van Drie JH
PROVIDER: S-EPMC4013342 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Publications
Protein folding, protein homeostasis, and cancer.
Chinese journal of cancer 20110201 2
Proteins fold into their functional 3-dimensional structures from a linear amino acid sequence. In vitro this process is spontaneous; while in vivo it is orchestrated by a specialized set of proteins, called chaperones. Protein folding is an ongoing cellular process, as cellular proteins constantly undergo synthesis and degradation. Here emerging links between this process and cancer are reviewed. This perspective both yields insights into the current struggle to develop novel cancer chemotherap ...[more]
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