Ontology highlight
ABSTRACT:
SUBMITTER: Neukomm LJ
PROVIDER: S-EPMC4013519 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Neukomm L J LJ Zeng S S Frei A P AP Huegli P A PA Hengartner M O MO
Cell death and differentiation 20140314 6
The rapid clearance of dying cells is important for the well-being of multicellular organisms. In C. elegans, cell corpse removal is mainly mediated by three parallel engulfment signaling cascades. These pathways include two small GTPases, MIG-2/RhoG and CED-10/Rac1. Here we present the identification and characterization of CDC-42 as a third GTPase involved in the regulation of cell corpse clearance. Genetic analyses performed by both loss of cdc-42 function and cdc-42 overexpression place cdc- ...[more]