Ontology highlight
ABSTRACT:
SUBMITTER: Rizzo G
PROVIDER: S-EPMC4013760 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Rizzo Gaia G Veronese Mattia M Heckemann Rolf A RA Selvaraj Sudhakar S Howes Oliver D OD Hammers Alexander A Turkheimer Federico E FE Bertoldo Alessandra A
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20140205 5
Substantial efforts are being spent on postmortem mRNA transcription mapping on the assumption that in vivo protein distribution can be predicted from such data. We tested this assumption by comparing mRNA transcription maps from the Allen Human Brain Atlas with reference protein concentration maps acquired with positron emission tomography (PET) in two representative systems of neurotransmission (opioid and serotoninergic). We found a tight correlation between mRNA expression and specific bindi ...[more]