Genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice.
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ABSTRACT:
SUBMITTER: Krohn J
PROVIDER: S-EPMC4014490 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice.
Krohn Jon J Speed Doug D Palme Rupert R Touma Chadi C Mott Richard R Flint Jonathan J
PloS one 20140508 5
The extent to which sex-specific genetic effects contribute to phenotypic variation is largely unknown. We applied a novel Bayesian method, sparse partitioning, to detect gene by sex (GxS) and gene by gene (GxG) quantitative loci (QTLs) in 1,900 outbred heterogeneous stock mice. In an analysis of 55 phenotypes, we detected 16 GxS and 6 GxG QTLs. The increase in the amount of phenotypic variance explained by models including GxS was small, ranging from 0.14% to 4.30%. We conclude that GxS rarely ...[more]
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