Ontology highlight
ABSTRACT:
SUBMITTER: Zaitlen N
PROVIDER: S-EPMC4244251 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Nature genetics 20141110 12
Despite recent progress on estimating the heritability explained by genotyped SNPs (h(2)g), a large gap between h(2)g and estimates of total narrow-sense heritability (h(2)) remains. Explanations for this gap include rare variants or upward bias in family-based estimates of h(2) due to shared environment or epistasis. We estimate h(2) from unrelated individuals in admixed populations by first estimating the heritability explained by local ancestry (h(2)γ). We show that h(2)γ = 2FSTCθ(1 - θ)h(2), ...[more]