Insights into miRNA regulation of the human glycome.
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ABSTRACT:
SUBMITTER: Kasper BT
PROVIDER: S-EPMC4015186 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
Insights into miRNA regulation of the human glycome.
Kasper Brian T BT Koppolu Sujeethraj S Mahal Lara K LK
Biochemical and biophysical research communications 20140123 4
Glycosylation is an intricate process requiring the coordinated action of multiple proteins, including glycosyltransferases, glycosidases, sugar nucleotide transporters and trafficking proteins. Work by several groups points to a role for microRNA (miRNA) in controlling the levels of specific glycosyltransferases involved in cancer, neural migration and osteoblast formation. Recent work in our laboratory suggests that miRNA are a principal regulator of the glycome, translating genomic informatio ...[more]
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