Dataset Information
Tolerance and physiological correlates of neuromuscular electrical stimulation in COPD: a pilot study.
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ABSTRACT: Rationale
Neuromuscular electrical stimulation (NMES) of the lower limbs is an emerging training strategy in patients with COPD. The efficacy of this technique is related to the intensity of the stimulation that is applied during the training sessions. However, little is known about tolerance to stimulation current intensity and physiological factors that could determine it. Our goal was to find potential physiological predictors of the tolerance to increasing NMES stimulation intensity in patients with mild to severe COPD.Methods
20 patients with COPD (FEV1?=?54±14% pred.) completed 2 supervised NMES sessions followed by 5 self-directed sessions at home and one final supervised session. NMES was applied simultaneously to both quadriceps for 45 minutes, at a stimulation frequency of 50 Hz. Spirometry, body composition, muscle function and aerobic capacity were assessed at baseline. Cardiorespiratory responses, leg discomfort, muscle fatigue and markers of systemic inflammation were assessed during or after the last NMES session. Tolerance to NMES was quantified as the increase in current intensity from the initial to the final NMES session (?Int).Results
Mean ?Int was 12±10 mA. FEV1, fat-free-mass, quadriceps strength, aerobic capacity and leg discomfort during the last NMES session positively correlated with ?Int (r?=?0.42 to 0.64, all p?0.06) while post/pre NMES IL-6 ratio negatively correlated with ?Int (r?=?-0.57, p?=?0.001). FEV1, leg discomfort during last NMES session and post/pre IL-6 ratio to NMES were independent factors of variance in ?Int (r2?=?0.72, p?=?0.001).Conclusion
Lower tolerance to NMES was associated with increasing airflow obstruction, low tolerance to leg discomfort during NMES and the magnitude of the IL-6 response after NMES.Trial registration
ClinicalTrials.gov NCT00809120.
SUBMITTER: Vivodtzev I
PROVIDER: S-EPMC4015894 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Tolerance and physiological correlates of neuromuscular electrical stimulation in COPD: a pilot study.
PloS one 20140509 5
<h4>Rationale</h4>Neuromuscular electrical stimulation (NMES) of the lower limbs is an emerging training strategy in patients with COPD. The efficacy of this technique is related to the intensity of the stimulation that is applied during the training sessions. However, little is known about tolerance to stimulation current intensity and physiological factors that could determine it. Our goal was to find potential physiological predictors of the tolerance to increasing NMES stimulation intensity ...[more]