Ontology highlight
ABSTRACT:
SUBMITTER: Veleva-Rotse BO
PROVIDER: S-EPMC4016016 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Veleva-Rotse Biliana O BO Smart James L JL Baas Annette F AF Edmonds Benjamin B Zhao Zi-ming ZM Brown Allyson A Klug Lillian R LR Hansen Kelly K Reilly Gabrielle G Gardner Alexandria P AP Subbiah Krishnaveni K Gaucher Eric A EA Clevers Hans H Barnes Anthony P AP
Neural development 20140304
<h4>Background</h4>Neuronal polarization is an essential step of morphogenesis and connectivity in the developing brain. The serine/threonine kinase LKB1 is a key regulator of cell polarity, metabolism, tumorigenesis, and is required for axon formation. It is allosterically regulated by two related and evolutionarily conserved pseudokinases, STe20-Related ADapters (STRADs) α and β. The roles of STRADα and STRADβ in the developing nervous system are not fully defined, nor is it known whether they ...[more]