Ontology highlight
ABSTRACT:
SUBMITTER: Samuel MA
PROVIDER: S-EPMC5369022 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Nature neuroscience 20140803 9
Age-related decreases in neural function result in part from alterations in synapses. To identify molecular defects that lead to such changes, we focused on the outer retina, in which synapses are markedly altered in old rodents and humans. We found that the serine/threonine kinase LKB1 and one of its substrates, AMPK, regulate this process. In old mice, synaptic remodeling was accompanied by specific decreases in the levels of total LKB1 and active (phosphorylated) AMPK. In the absence of eithe ...[more]