Unknown

Dataset Information

0

Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis.


ABSTRACT: Cancer-secreted microRNAs (miRNAs) are emerging mediators of cancer-host crosstalk. Here we show that miR-105, which is characteristically expressed and secreted by metastatic breast cancer cells, is a potent regulator of migration through targeting the tight junction protein ZO-1. In endothelial monolayers, exosome-mediated transfer of cancer-secreted miR-105 efficiently destroys tight junctions and the integrity of these natural barriers against metastasis. Overexpression of miR-105 in nonmetastatic cancer cells induces metastasis and vascular permeability in distant organs, whereas inhibition of miR-105 in highly metastatic tumors alleviates these effects. miR-105 can be detected in the circulation at the premetastatic stage, and its levels in the blood and tumor are associated with ZO-1 expression and metastatic progression in early-stage breast cancer.

SUBMITTER: Zhou W 

PROVIDER: S-EPMC4016197 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications


Cancer-secreted microRNAs (miRNAs) are emerging mediators of cancer-host crosstalk. Here we show that miR-105, which is characteristically expressed and secreted by metastatic breast cancer cells, is a potent regulator of migration through targeting the tight junction protein ZO-1. In endothelial monolayers, exosome-mediated transfer of cancer-secreted miR-105 efficiently destroys tight junctions and the integrity of these natural barriers against metastasis. Overexpression of miR-105 in nonmeta  ...[more]

Similar Datasets

| S-EPMC4380143 | biostudies-literature
| S-EPMC7962220 | biostudies-literature
| S-EPMC3892109 | biostudies-literature
2024-08-31 | GSE222708 | GEO
| S-EPMC5785248 | biostudies-literature
| S-EPMC5572936 | biostudies-literature
| S-EPMC5920728 | biostudies-literature
2024-08-31 | GSE222707 | GEO
| S-EPMC6857047 | biostudies-literature
| S-EPMC6131784 | biostudies-literature