Ontology highlight
ABSTRACT:
SUBMITTER: Zhou W
PROVIDER: S-EPMC4016197 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Zhou Weiying W Fong Miranda Y MY Min Yongfen Y Somlo George G Liu Liang L Palomares Melanie R MR Yu Yang Y Chow Amy A O'Connor Sean Timothy Francis ST Chin Andrew R AR Yen Yun Y Wang Yafan Y Marcusson Eric G EG Chu Peiguo P Wu Jun J Wu Xiwei X Li Arthur Xuejun AX Li Zhuo Z Gao Hanlin H Ren Xiubao X Boldin Mark P MP Lin Pengnian Charles PC Wang Shizhen Emily SE
Cancer cell 20140401 4
Cancer-secreted microRNAs (miRNAs) are emerging mediators of cancer-host crosstalk. Here we show that miR-105, which is characteristically expressed and secreted by metastatic breast cancer cells, is a potent regulator of migration through targeting the tight junction protein ZO-1. In endothelial monolayers, exosome-mediated transfer of cancer-secreted miR-105 efficiently destroys tight junctions and the integrity of these natural barriers against metastasis. Overexpression of miR-105 in nonmeta ...[more]