Ontology highlight
ABSTRACT:
SUBMITTER: Fong MY
PROVIDER: S-EPMC4380143 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Nature cell biology 20150126 2
Reprogrammed glucose metabolism as a result of increased glycolysis and glucose uptake is a hallmark of cancer. Here we show that cancer cells can suppress glucose uptake by non-tumour cells in the premetastatic niche, by secreting vesicles that carry high levels of the miR-122 microRNA. High miR-122 levels in the circulation have been associated with metastasis in breast cancer patients, and we show that cancer-cell-secreted miR-122 facilitates metastasis by increasing nutrient availability in ...[more]