Visualizing dermal permeation of sodium channel modulators by mass spectrometric imaging.
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ABSTRACT:
SUBMITTER: Eberlin LS
PROVIDER: S-EPMC4017602 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
Visualizing dermal permeation of sodium channel modulators by mass spectrometric imaging.
Eberlin Livia S LS Mulcahy John V JV Tzabazis Alexander A Zhang Jialing J Liu Huwei H Logan Matthew M MM Roberts Heather J HJ Lee Gordon K GK Yeomans David C DC Du Bois Justin J Zare Richard N RN
Journal of the American Chemical Society 20140417 17
Determining permeability of a given compound through human skin is a principal challenge owing to the highly complex nature of dermal tissue. We describe the application of an ambient mass spectrometry imaging method for visualizing skin penetration of sodium channel modulators, including novel synthetic analogs of natural neurotoxic alkaloids, topically applied ex vivo to human skin. Our simple and label-free approach enables successful mapping of the transverse and lateral diffusion of small m ...[more]
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