Ontology highlight
ABSTRACT:
SUBMITTER: Wlodarska M
PROVIDER: S-EPMC4017640 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Wlodarska Marta M Thaiss Christoph A CA Nowarski Roni R Henao-Mejia Jorge J Zhang Jian-Ping JP Brown Eric M EM Frankel Gad G Levy Maayan M Katz Meirav N MN Philbrick William M WM Elinav Eran E Finlay B Brett BB Flavell Richard A RA
Cell 20140201 5
Mucus production by goblet cells of the large intestine serves as a crucial antimicrobial protective mechanism at the interface between the eukaryotic and prokaryotic cells of the mammalian intestinal ecosystem. However, the regulatory pathways involved in goblet cell-induced mucus secretion remain largely unknown. Here, we demonstrate that the NLRP6 inflammasome, a recently described regulator of colonic microbiota composition and biogeographical distribution, is a critical orchestrator of gobl ...[more]