QGRS-Conserve: a computational method for discovering evolutionarily conserved G-quadruplex motifs.

ABSTRACT:

Background

Nucleic acids containing guanine tracts can form quadruplex structures via non-Watson-Crick base pairing. Formation of G-quadruplexes is associated with the regulation of important biological functions such as transcription, genetic instability, DNA repair, DNA replication, epigenetic mechanisms, regulation of translation, and alternative splicing. G-quadruplexes play important roles in human diseases and are being considered as targets for a variety of therapies. Identification of functional G-quadruplexes and the study of their overall distribution in genomes and transcriptomes is an important pursuit. Traditional computational methods map sequence motifs capable of forming G-quadruplexes but have difficulty in distinguishing motifs that occur by chance from ones which

SUBMITTER: Frees S 

PROVIDER: S-EPMC4017754 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature