Ontology highlight
ABSTRACT:
SUBMITTER: Arisawa M
PROVIDER: S-EPMC4017980 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20110317 5
Conformationally restricted indomethacin analogues were designed and prepared from the corresponding 2-substituted indoles, which were synthesized by a one-pot isomerization/enamide-ene metathesis as the key reaction. Conformational analysis by calculations, NMR studies, and X-ray crystallography suggested that these analogues were conformationally restricted in the s-cis or the s-trans form due to the 2-substituent as expected. Their biological activities on cyclooxygenase-1 (COX-1) inhibition, ...[more]