Nitric oxide donor doxorubicins accumulate into Doxorubicin-resistant human colon cancer cells inducing cytotoxicity.
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ABSTRACT:
SUBMITTER: Chegaev K
PROVIDER: S-EPMC4018161 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
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Nitric oxide donor doxorubicins accumulate into Doxorubicin-resistant human colon cancer cells inducing cytotoxicity.
Chegaev Konstantin K Riganti Chiara C Lazzarato Loretta L Rolando Barbara B Guglielmo Stefano S Campia Ivana I Fruttero Roberta R Bosia Amalia A Gasco Alberto A
ACS medicinal chemistry letters 20110404 7
Products 4 and 5, obtained by conjugation of doxorubicin with nitric oxide (NO) donor nitrooxy and phenylsulfonyl furoxan moieties, respectively, accumulate in doxorubicin-resistant human colon cancer cells (HT29-dx), inducing high cytotoxicity. This behavior parallels the ability of the compounds to generate NO, detected as nitrite, in these cells. Preliminary immunoblotting studies suggest that the mechanism that underlies the cytotoxic effect could involve inhibition of cellular drug efflux d ...[more]
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