Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140.
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ABSTRACT:
SUBMITTER: Miller CP
PROVIDER: S-EPMC4018048 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Publications
Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140.
Miller Chris P CP Shomali Maysoun M Lyttle C Richard CR O'Dea Louis St L LS Herendeen Hillary H Gallacher Kyla K Paquin Dottie D Compton Dennis R DR Sahoo Bishwabhusan B Kerrigan Sean A SA Burge Matthew S MS Nickels Michael M Green Jennifer L JL Katzenellenbogen John A JA Tchesnokov Alexei A Hattersley Gary G
ACS medicinal chemistry letters 20101202 2
This report describes the discovery of RAD140, a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM). The characterization of RAD140 in several preclinical models of anabolic androgen action is also described. ...[more]
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