Ontology highlight
ABSTRACT:
SUBMITTER: Landrieu I
PROVIDER: S-EPMC4018068 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20110405 6
Cyclosporine A (CsA) and its chemical analogues EthVal4Cs, MeVal4Cs, and Me(d-Ala)3EthVal4Cs (Alisporivir) all interact with cyclophilin A (CypA). The latter Alisporivir is a nonimmunosuppressive CsA derivative that has potent anti-HCV properties in clinical trials. We show here that NMR spectroscopy can be used to rank this series of related pharmacological molecules despite their high affinity for the target protein and low solubility in water. The novel method is based on the possibility to d ...[more]