Ontology highlight
ABSTRACT:
SUBMITTER: Zhong H
PROVIDER: S-EPMC4018105 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Zhong Haizhen H Wees Melissa A MA Faure Theresa D TD Carrillo Carol C Arbiser Jack J Bowen J Phillip JP
ACS medicinal chemistry letters 20110329 6
The influence of ionization states of hydroxamates and retrohydroxamates and the presence of zinc ions in the active site were investigated using the wild-type and E402Q mutant of MMP-9. The deprotonated hydroxamates showed a significantly enhanced enrichment factor in the presence of zinc ions. A pharmacophore model was developed based on the deprotonated compounds and was used to identify four structurally diverse compounds with antiproliferative activities. ...[more]