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Synthesis and antibacterial activity of a novel class of 15-membered macrolide antibiotics, "11a-azalides".

ABSTRACT: An efficient method for the reconstruction of the 9-dihydroerythromycin A macrolactone skeleton has been established. The key steps are oxidative cleavage at the 11,12-position and reconstruction after insertion of an appropriate functionalized amino alcohol. Novel 15-membered macrolides, we named as "11a-azalides", were synthesized based on the above methodology and evaluated for their antibacterial activity. Among them, (13R)-benzyloxymethyl-11a-azalide showed the most potent Streptococcus pneumoniae activity, with improved activity against a representative erythromycin-resistant strain compared to clarithromycin (CAM).

SUBMITTER: Sugimoto T

PROVIDER: S-EPMC4018107 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Synthesis and antibacterial activity of a novel class of 15-membered macrolide antibiotics, "11a-azalides".

Sugimoto Tomohiro T Tanikawa Tetsuya T

ACS medicinal chemistry letters 20101230 3

An efficient method for the reconstruction of the 9-dihydroerythromycin A macrolactone skeleton has been established. The key steps are oxidative cleavage at the 11,12-position and reconstruction after insertion of an appropriate functionalized amino alcohol. Novel 15-membered macrolides, we named as "11a-azalides", were synthesized based on the above methodology and evaluated for their antibacterial activity. Among them, (13R)-benzyloxymethyl-11a-azalide showed the most potent Streptococcus pne ...[more]

PMID: 24900300

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