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Two new point mutations at A2062 associated with resistance to 16-membered macrolide antibiotics in mutant strains of Mycoplasma hominis.

ABSTRACT: We describe two mutants of Mycoplasma hominis PG-21 which show resistance to 16-membered macrolides but susceptibility to lincosamides, obtained by in vitro exposure to increasing doses of josamycin. The 23S rRNA gene showed that each had a mutation (A2062G and A2062T) corresponding to nucleotide 2062 in Escherichia coli, which was associated with the acquired phenotype.

SUBMITTER: Furneri PM

PROVIDER: S-EPMC90764 | biostudies-literature | 2001 Oct

REPOSITORIES: biostudies-literature

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Two new point mutations at A2062 associated with resistance to 16-membered macrolide antibiotics in mutant strains of Mycoplasma hominis.

Furneri P M PM Rappazzo G G Musumarra M P MP Di Pietro P P Catania L S LS Roccasalva L S LS

Antimicrobial agents and chemotherapy 20011001 10

We describe two mutants of Mycoplasma hominis PG-21 which show resistance to 16-membered macrolides but susceptibility to lincosamides, obtained by in vitro exposure to increasing doses of josamycin. The 23S rRNA gene showed that each had a mutation (A2062G and A2062T) corresponding to nucleotide 2062 in Escherichia coli, which was associated with the acquired phenotype. ...[more]

PMID: 11557502

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