Ontology highlight
ABSTRACT:
SUBMITTER: Amato G
PROVIDER: S-EPMC4018159 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20110331 6
A series of N-pyridyl benzamide KCNQ2/Q3 potassium channel openers were identified and found to be active in animal models of epilepsy and pain. The best compound 12 [ICA-027243, N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide] has an EC50 of 0.38 μM and is selective for KCNQ2/Q3 channels. This compound was active in several rodent models of epilepsy and pain but upon repeated dosing had a number of unacceptable toxicities that prevented further development. On the basis of the structure-activi ...[more]