Ontology highlight
ABSTRACT:
SUBMITTER: Wu NC
PROVIDER: S-EPMC4018626 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Wu Nicholas C NC Young Arthur P AP Al-Mawsawi Laith Q LQ Olson C Anders CA Feng Jun J Qi Hangfei H Chen Shu-Hwa SH Lu I-Hsuan IH Lin Chung-Yen CY Chin Robert G RG Luan Harding H HH Nguyen Nguyen N Nelson Stanley F SF Li Xinmin X Wu Ting-Ting TT Sun Ren R
Scientific reports 20140513
Genetic research on influenza virus biology has been informed in large part by nucleotide variants present in seasonal or pandemic samples, or individual mutants generated in the laboratory, leaving a substantial part of the genome uncharacterized. Here, we have developed a single-nucleotide resolution genetic approach to interrogate the fitness effect of point mutations in 98% of the amino acid positions in the influenza A virus hemagglutinin (HA) gene. Our HA fitness map provides a reference t ...[more]