Ontology highlight
ABSTRACT:
SUBMITTER: Riddle RC
PROVIDER: S-EPMC4019037 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Riddle Ryan C RC Frey Julie L JL Tomlinson Ryan E RE Ferron Mathieu M Li Yuanyuan Y DiGirolamo Douglas J DJ Faugere Marie-Claude MC Hussain Mehboob A MA Karsenty Gerard G Clemens Thomas L TL
Molecular and cellular biology 20140303 10
Insulin signaling in osteoblasts regulates global energy balance by stimulating the production of osteocalcin, a bone-derived protein that promotes insulin production and action. To identify the signaling pathways in osteoblasts that mediate insulin's effects on bone and energy metabolism, we examined the function of the tuberous sclerosis 2 (Tsc2) protein, a key target important in coordinating nutrient signaling. Here, we show that loss of Tsc2 in osteoblasts constitutively activates mTOR and ...[more]