In vivo splenic clearance correlates with in vitro deformability of red blood cells from Plasmodium yoelii-infected mice.
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ABSTRACT:
SUBMITTER: Huang S
PROVIDER: S-EPMC4019160 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
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In vivo splenic clearance correlates with in vitro deformability of red blood cells from Plasmodium yoelii-infected mice.
Huang Sha S Amaladoss Anburaj A Liu Min M Chen Huichao H Zhang Rou R Preiser Peter R PR Dao Ming M Han Jongyoon J
Infection and immunity 20140331 6
Recent experimental and clinical studies suggest a crucial role of mechanical splenic filtration in the host's defense against malaria parasites. Subtle changes in red blood cell (RBC) deformability, caused by infection or drug treatment, could influence the pathophysiological outcome. However, in vitro deformability measurements have not been directly linked in vivo with the splenic clearance of RBCs. In this study, mice infected with malaria-inducing Plasmodium yoelii revealed that chloroquine ...[more]
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