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Screening for HIV-associated peripheral neuropathy in resource-limited settings.

ABSTRACT: Peripheral neuropathy is the most common neurological complication of human immunodeficiency virus (HIV) infection but is widely under-diagnosed in resource-limited settings. We investigated the utility of screening tools administered by nonphysician healthcare workers (HCW) and quantitative sensory testing (QST) administered by trained individuals for identification of moderate/severe neuropathy.We enrolled 240 HIV-infected outpatients using 2-stage cluster randomized sampling. HCWs administered the several screening tools. Trained study staff performed QST. Tools were validated against a clinical diagnosis of neuropathy.Participants were 65% women, mean age 36.4 years, median CD4 324 cells/?L. A total of 65% were taking antiretrovirals, and 18% had moderate/severe neuropathy. The screening tests were 76% sensitive in diagnosing moderate/severe neuropathy with negative predictive values of 84-92%. QST was less sensitive but more specific.Screening tests administered by HCW have excellent negative predictive values and are promising tools for scale-up in resource-limited settings. QST shows promise for research use.

SUBMITTER: Cettomai D

PROVIDER: S-EPMC4019398 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Screening for HIV-associated peripheral neuropathy in resource-limited settings.

Cettomai Deanna D Kwasa Judith K JK Birbeck Gretchen L GL Price Richard W RW Cohen Craig R CR Bukusi Elizabeth A EA Kendi Caroline C Meyer Ana-Claire L AC

Muscle & nerve 20130827 4

<h4>Introduction</h4>Peripheral neuropathy is the most common neurological complication of human immunodeficiency virus (HIV) infection but is widely under-diagnosed in resource-limited settings. We investigated the utility of screening tools administered by nonphysician healthcare workers (HCW) and quantitative sensory testing (QST) administered by trained individuals for identification of moderate/severe neuropathy.<h4>Methods</h4>We enrolled 240 HIV-infected outpatients using 2-stage cluster ...[more]

PMID: 24037693

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Dataset Information

Screening for HIV-associated peripheral neuropathy in resource-limited settings.

Publications

Screening for HIV-associated peripheral neuropathy in resource-limited settings.

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