Ontology highlight
ABSTRACT:
SUBMITTER: Moreno E
PROVIDER: S-EPMC4020086 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Moreno Elena E Ojosnegros Samuel S García-Arriaza Juan J Escarmís Cristina C Domingo Esteban E Perales Celia C
Proceedings of the National Academy of Sciences of the United States of America 20140422 18
The mechanisms of viral RNA genome segmentation are unknown. On extensive passage of foot-and-mouth disease virus in baby hamster kidney-21 cells, the virus accumulated multiple point mutations and underwent a transition akin to genome segmentation. The standard single RNA genome molecule was replaced by genomes harboring internal in-frame deletions affecting the L- or capsid-coding region. These genomes were infectious and killed cells by complementation. Here we show that the point mutations i ...[more]