Ontology highlight
ABSTRACT:
SUBMITTER: Cymer F
PROVIDER: S-EPMC4400336 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Cymer Florian F Hedman Rickard R Ismail Nurzian N von Heijne Gunnar G
The Journal of biological chemistry 20150224 16
Translational arrest peptides (APs) are short stretches of polypeptides that induce translational stalling when synthesized on a ribosome. Mechanical pulling forces acting on the nascent chain can weaken or even abolish stalling. APs can therefore be used as in vivo force sensors, making it possible to measure the forces that act on a nascent chain during translation with single-residue resolution. It is also possible to score the relative strengths of APs by subjecting them to a given pulling f ...[more]