ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation.
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ABSTRACT:
SUBMITTER: Wei J
PROVIDER: S-EPMC4020202 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation.
Wei Jianlu J Richbourgh Brendon B Jia Tanghong T Liu Chuanju C
Mediators of inflammation 20140428
ADAMTS-12 is a member of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family of proteases, which were known to play important roles in various biological and pathological processes, such as development, angiogenesis, inflammation, cancer, arthritis, and atherosclerosis. In this review, we briefly summarize the structural organization of ADAMTS-12; concentrate on the emerging role of ADAMTS-12 in several pathophysiological conditions, including intervertebral disc degen ...[more]
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