ADAMTS-18: a metalloproteinase with multiple functions.
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ABSTRACT:
SUBMITTER: Wei J
PROVIDER: S-EPMC4410865 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
ADAMTS-18: a metalloproteinase with multiple functions.
Wei Jianlu J Liu Chuan-ju CJ Li Zongdong Z
Frontiers in bioscience (Landmark edition) 20140601 8
ADAMTS-18 is a member of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family of proteases, which are known to play important roles in development, angiogenesis and coagulation; dysregulation and mutation of these enzymes have been implicated in many disease processes, such as inflammation, cancer, arthritis and atherosclerosis. Mutations of ADAMTS-18 have been linked to abnormal early eye development and reduced bone mineral density. In this review, we briefly summariz ...[more]
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