Protein languages differ depending on microorganism lifestyle.

ABSTRACT: Few quantitative measures of genome architecture or organization exist to support assumptions of differences between microorganisms that are broadly defined as being free-living or pathogenic. General principles about complete proteomes exist for codon usage, amino acid biases and essential or core genes. Genome-wide shifts in amino acid usage between free-living and pathogenic microorganisms result in fundamental differences in the complexity of their respective proteomes that are size and gene content independent. These differences are evident across broad phylogenetic groups-a result of environmental factors and population genetic forces rather than phylogenetic distance. A novel comparative analysis of amino acid usage-utilizing linguistic analyses of word frequency in language and tex

SUBMITTER: Grzymski JJ 

PROVIDER: S-EPMC4020791 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature