Ontology highlight
ABSTRACT:
SUBMITTER: Bastain TM
PROVIDER: S-EPMC4020940 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Bastain T M TM Islam T T Berhane K T KT McConnell R S RS Rappaport E B EB Salam M T MT Linn W S WS Avol E L EL Zhang Y Y Gilliland F D FD
The European respiratory journal 20100715 3
A substantial body of evidence suggests an aetiological role of inflammation, and oxidative and nitrosative stress in asthma pathogenesis. Exhaled nitric oxide fraction (F(eNO)) may provide a noninvasive marker of oxidative and nitrosative stress, and aspects of airway inflammation. We examined whether children with elevated F(eNO) are at increased risk for new-onset asthma. We prospectively followed 2,206 asthma-free children (age 7-10 yrs) who participated in the Children's Health Study. We me ...[more]