Dataset Information

Urinary and breast milk biomarkers to assess exposure to naphthalene in pregnant women: an investigation of personal and indoor air sources.

ABSTRACT:

Background

Naphthalene exposures for most non-occupationally exposed individuals occur primarily indoors at home. Residential indoor sources include pest control products (specifically moth balls), incomplete combustion such as cigarette smoke, woodstoves and cooking, some consumer and building products, and emissions from gasoline sources found in attached garages. The study aim was to assess naphthalene exposure in pregnant women from Canada, using air measurements and biomarkers of exposure.

Methods

Pregnant women residing in Ottawa, Ontario completed personal and indoor air sampling, and questionnaires. During pregnancy, pooled urine voids were collected over two 24-hour periods on a weekday and a weekend day. At 2-3 months post-birth, they provided a spot urine sample and a breast milk sample following the 24-hour air monitoring. Urines were analyzed for 1-naphthol and 2-naphthol and breast milk for naphthalene. Simple linear regression models examined associations between known naphthalene sources, air and biomarker samples.

Results

Study recruitment rate was 11.2% resulting in 80 eligible women being included. Weekday and weekend samples were highly correlated for both personal (r?=?0.83, p?ConclusionsMedian urinary concentrations of naphthalene metabolites tended to be similar to (1-naphthol) or lower (2-naphthol) than those reported in a Canadian survey of women of reproductive age. Only urinary 1-naphthol and naphthalene in breast milk were associated. Potential reasons for the lack of other associations include a lack of sources, varying biotransformation rates and behavioural differences over time.

SUBMITTER: Wheeler AJ

PROVIDER: S-EPMC4021493 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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Publications

Urinary and breast milk biomarkers to assess exposure to naphthalene in pregnant women: an investigation of personal and indoor air sources.

Wheeler Amanda J AJ Dobbin Nina A NA Héroux Marie-Eve ME Fisher Mandy M Sun Liu L Khoury Cheryl F CF Hauser Russ R Walker Mark M Ramsay Tim T Bienvenu Jean-François JF LeBlanc Alain A Daigle Eric E Gaudreau Eric E Belanger Patrick P Feeley Mark M Ayotte Pierre P Arbuckle Tye E TE

Environmental health : a global access science source 20140427 1

<h4>Background</h4>Naphthalene exposures for most non-occupationally exposed individuals occur primarily indoors at home. Residential indoor sources include pest control products (specifically moth balls), incomplete combustion such as cigarette smoke, woodstoves and cooking, some consumer and building products, and emissions from gasoline sources found in attached garages. The study aim was to assess naphthalene exposure in pregnant women from Canada, using air measurements and biomarkers of ex ...[more]

PMID: 24767676

Similar Datasets

Project description:BackgroundPersonal and indoor air pollution monitors represent two ways to assess acute air pollution exposures; however, few reproductive epidemiology studies have incorporated these tools.ObjectiveTo provide an overview of the unique challenges and opportunities that arise when measuring acute exposure to air pollution in two ongoing reproductive epidemiology studies.MethodsThe Air Pollution, In Vitro Fertilization (IVF), and Reproductive Outcomes (AIR) Study recruits women undergoing IVF to wear a personal particulate matter (PM) air pollution monitor (AirBeam2©) for the 72-hour period following the start of controlled ovarian stimulation. The Reproductive Effects of Chemicals and Air Pollutants (RECAP) Study recruits men across the United States to place an air pollution monitor (emmET) in their home for 3 months, use a smartphone application, and provide a semen sample. We highlight the key issues identified in implementing exposure assessment for both studies.ResultsThe main advantages of using the AirBeam2© personal monitor are as follows: (a) the low cost, (b) the ability to collect multiple size fractions of PM data every second, (c) the portability, (d) its capability to track GPS location, and (e) the ability for the participant to observe their real-time exposure information. The limited battery life, incompatibility with iOS-based smartphones, and frequent connection issues that arise between the AirBeam2© and smartphone are the main disadvantages. The main advantages of the emmET are the ability to measure multiple air pollutants at a high level of accuracy, collect data for a long period of time without burdening the participant, and ship monitors to participants around the country without the need for in-person set-up by trained technicians; however, the monitor only measures the indoor home environment.ConclusionsNovel methods can be utilised to characterise short-term air pollution exposure in reproductive epidemiology studies and represent an exciting area for future research.

Dataset Information

Urinary and breast milk biomarkers to assess exposure to naphthalene in pregnant women: an investigation of personal and indoor air sources.

Background

Methods

Results

Publications

Urinary and breast milk biomarkers to assess exposure to naphthalene in pregnant women: an investigation of personal and indoor air sources.

Similar Datasets

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