Ontology highlight
ABSTRACT:
SUBMITTER: Joss-Moore L
PROVIDER: S-EPMC4021738 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Joss-Moore Lisa L Carroll Travis T Yang Yan Y Fitzhugh Melanie M Metcalfe Drew D Oman Jake J Hale Merica M Dong Li L Wang Zheng-Ming ZM Yu Xing X Callaway Christopher W CW O'Brien Elizabeth E McKnight Robert A RA Lane Robert H RH Albertine Kurt H KH
Pediatric research 20130218 5
<h4>Background</h4>We showed that intrauterine growth restriction (IUGR) increases distal airspace wall thickness at birth (postnatal age 0; P0) in rat pups (saccular stage of lung development). However, that report did not assess whether the saccular phenotype persisted postnatally or occurred in males or females, nor did the report identify a potential molecular pathway for the saccular phenotype at P0. We hypothesized that IUGR persistently delays alveolar formation and disrupts retinoic acid ...[more]