MiR-199a-5p regulates sirtuin1 and PI3K in the rat hippocampus with intrauterine growth restriction.
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ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC6138635 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
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MiR-199a-5p regulates sirtuin1 and PI3K in the rat hippocampus with intrauterine growth restriction.
Chen Juncao J Gong Xiaoyun X Huang Li L Chen Pingyang P Wang Tao T Zhou Wei W Luo Kaiju K Wang Jing J
Scientific reports 20180914 1
In humans, malnutrition during pregnancy results in intrauterine growth restriction (IUGR) and an increased risk of neurological morbidities; altered miRNA characteristics have been suggested to contribute to IUGR neurological pathogenesis. A miRNA microarray was used to identify differentially expressed miRNA molecules in the hippocampi of rats with IUGR. Five of the molecules in question were selectively validated using real-time PCR in rats with IUGR. We then investigated the role of miR-199a ...[more]
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