Ontology highlight
ABSTRACT:
SUBMITTER: Kim DG
PROVIDER: S-EPMC4021855 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Nature chemical biology 20131110 1
Lysyl-tRNA synthetase (KRS), a protein synthesis enzyme in the cytosol, relocates to the plasma membrane after a laminin signal and stabilizes a 67-kDa laminin receptor (67LR) that is implicated in cancer metastasis; however, its potential as an antimetastatic therapeutic target has not been explored. We found that the small compound BC-K-YH16899, which binds KRS, impinged on the interaction of KRS with 67LR and suppressed metastasis in three different mouse models. The compound inhibited the KR ...[more]