Immune checkpoints: A therapeutic target in triple negative breast cancer.
Ontology highlight
ABSTRACT:
SUBMITTER: Chawla A
PROVIDER: S-EPMC4022604 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Publications
Immune checkpoints: A therapeutic target in triple negative breast cancer.
Chawla Akhil A Philips Anne V AV Alatrash Gheath G Mittendorf Elizabeth E
Oncoimmunology 20140101 3
Early clinical trials investigating monoclonal antibodies targeting the T-cell inhibitory receptor programmed cell death 1 (PD-1) and its ligand PD-L1 have shown efficacy in melanoma, non-small cell lung cancer and renal cell carcinoma. We recently demonstrated PD-L1 expression in 20% of triple negative breast cancers suggesting that targeting the PD-1/PD-L1 immune checkpoint may be an effective treatment modality in patients with this disease. ...[more]
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