Ontology highlight
ABSTRACT:
SUBMITTER: Werner-Klein M
PROVIDER: S-EPMC4022674 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Werner-Klein Melanie M Proske Judith J Werno Christian C Schneider Katharina K Hofmann Hans-Stefan HS Rack Brigitte B Buchholz Stefan S Ganzer Roman R Blana Andreas A Seelbach-Göbel Birgit B Nitsche Ulrich U Männel Daniela N DN Klein Christoph A CA
PloS one 20140515 5
Tumor xenografts in immunodeficient mice, while routinely used in cancer research, preclude studying interactions of immune and cancer cells or, if humanized by allogeneic immune cells, are of limited use for tumor-immunological questions. Here, we explore a novel way to generate cancer models with an autologous humanized immune system. We demonstrate that hematopoietic stem and progenitor cells (HSPCs) from bone marrow aspirates of non-metastasized carcinoma patients, which are taken at special ...[more]