Ontology highlight
ABSTRACT:
SUBMITTER: Harvestine JN
PROVIDER: S-EPMC7015678 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Harvestine J N JN Gonzalez-Fernandez T T Sebastian A A Hum N R NR Genetos D C DC Loots G G GG Leach J K JK
Science advances 20200212 7
Cell-derived extracellular matrix (ECM) provides a niche to promote osteogenic differentiation, cell adhesion, survival, and trophic factor secretion. To determine whether osteogenic preconditioning would improve the bone-forming potential of unfractionated bone marrow aspirate (BMA), we perfused cells on ECM-coated scaffolds to generate naïve and preconditioned constructs, respectively. The composition of cells selected from BMA was distinct on each scaffold. Naïve constructs exhibited robust p ...[more]