Poly (ADP-ribose) polymerase inhibitor: an evolving paradigm in the treatment of prostate cancer.
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ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC4023365 | biostudies-literature | 2014 May-Jun
REPOSITORIES: biostudies-literature
Publications
Poly (ADP-ribose) polymerase inhibitor: an evolving paradigm in the treatment of prostate cancer.
Asian journal of andrology 20140501 3
Recent phase I studies have reported single-agent activities of poly (ADP-ribose) polymerase (PARP) inhibitor in sporadic and in BRCA-mutant prostate cancers. Two of the most common genetic alterations in prostate cancer, ETS gene rearrangement and loss of PTEN, have been linked to increased sensitivity to PARP inhibitor in preclinical models. Emerging evidence also suggests that PARP1 plays an important role in mediating the transcriptional activities of androgen receptor (AR) and ETS gene rear ...[more]
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