Unknown

Dataset Information

0

High expression of IGFBP2 is associated with chemoresistance in adult acute myeloid leukemia.


ABSTRACT: Insulin-like growth factor (IGF) signaling plays an important role in many tumors and overexpression of IGF Binding Protein (IGFBP) 2 has been associated with adverse outcome in childhood leukemia. Here, we evaluated IGFBP2 mRNA expression and its prognostic implications in 99 adult acute myeloid leukemia (AML) patients by quantitative real-time RT-PCR. High IGFBP2 was associated with a high incidence of primary resistant disease (IGFBP2 high 65%, IGFBP2 low 32%; P=0.02) and was independently predictive for therapy resistance [OR 3.6 (95% CI 1.2-11); P=0.02] in multivariate analyses. Gene-expression profiling revealed an up-regulation of genes implicated in leukemogenesis (MYB, MEIS1, HOXB3, HOXA9) and genes associated with adverse outcome (ERG, WT1) in patients with high IGFBP2 expression. Thus, our data suggest a role of IGFBP2 and IGF signaling in chemoresistance of AML. Patients with high IGFBP2 expression might benefit from molecular therapies targeting the IGF pathway.

SUBMITTER: Kuhnl A 

PROVIDER: S-EPMC4023812 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

High expression of IGFBP2 is associated with chemoresistance in adult acute myeloid leukemia.

Kühnl Andrea A   Kaiser Martin M   Neumann Martin M   Fransecky Lars L   Heesch Sandra S   Radmacher Michael M   Marcucci Guido G   Bloomfield Clara D CD   Hofmann Wolf-Karsten WK   Thiel Eckhard E   Baldus Claudia D CD  

Leukemia research 20110906 12


Insulin-like growth factor (IGF) signaling plays an important role in many tumors and overexpression of IGF Binding Protein (IGFBP) 2 has been associated with adverse outcome in childhood leukemia. Here, we evaluated IGFBP2 mRNA expression and its prognostic implications in 99 adult acute myeloid leukemia (AML) patients by quantitative real-time RT-PCR. High IGFBP2 was associated with a high incidence of primary resistant disease (IGFBP2 high 65%, IGFBP2 low 32%; P=0.02) and was independently pr  ...[more]

Similar Datasets

| S-EPMC7493249 | biostudies-literature
| S-EPMC9780537 | biostudies-literature
| S-EPMC5096802 | biostudies-other
| S-EPMC7072365 | biostudies-literature
| S-EPMC5854918 | biostudies-literature
| S-EPMC8086305 | biostudies-literature
| S-EPMC4941280 | biostudies-literature
| S-EPMC3668829 | biostudies-literature
| S-EPMC10513429 | biostudies-literature
| S-EPMC8632764 | biostudies-literature