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MiRNA polymorphisms and risk of gastric cancer in Asian population.

ABSTRACT: miRNAs are endogenous 19- to 25-nt noncoding RNAs that can negatively regulate gene expression by directly cleaving target mRNA or by inhibiting its translation. Recent studies have revealed that miRNA plays a significant role in gastric cancer development either as a tumor suppressor gene or oncogene. miRNA-single-nucleotide polymorphisms (SNPs), as a novel class of functional SNPs/polymorphisms, have been identified as candidate biomarkers for gastric cancer susceptibility. On the basis of recent data, the present review summarizes current knowledge of the functional effects of miRNA-SNPs and their importance as candidate gastric cancer biomarkers. Additionally, this review also includes a meta-analysis of the most frequently studied miRNA-SNPs in gastric cancer.

SUBMITTER: Hua HB

PROVIDER: S-EPMC4024780 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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miRNA polymorphisms and risk of gastric cancer in Asian population.

Hua Hai-Bing HB Yan Ting-Ting TT Sun Qing-Min QM

World journal of gastroenterology 20140501 19

miRNAs are endogenous 19- to 25-nt noncoding RNAs that can negatively regulate gene expression by directly cleaving target mRNA or by inhibiting its translation. Recent studies have revealed that miRNA plays a significant role in gastric cancer development either as a tumor suppressor gene or oncogene. miRNA-single-nucleotide polymorphisms (SNPs), as a novel class of functional SNPs/polymorphisms, have been identified as candidate biomarkers for gastric cancer susceptibility. On the basis of rec ...[more]

PMID: 24914331

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