MiRNA polymorphisms and risk of gastric cancer in Asian population.
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ABSTRACT:
SUBMITTER: Hua HB
PROVIDER: S-EPMC4024780 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
miRNA polymorphisms and risk of gastric cancer in Asian population.
Hua Hai-Bing HB Yan Ting-Ting TT Sun Qing-Min QM
World journal of gastroenterology 20140501 19
miRNAs are endogenous 19- to 25-nt noncoding RNAs that can negatively regulate gene expression by directly cleaving target mRNA or by inhibiting its translation. Recent studies have revealed that miRNA plays a significant role in gastric cancer development either as a tumor suppressor gene or oncogene. miRNA-single-nucleotide polymorphisms (SNPs), as a novel class of functional SNPs/polymorphisms, have been identified as candidate biomarkers for gastric cancer susceptibility. On the basis of rec ...[more]
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