Ontology highlight
ABSTRACT:
SUBMITTER: Chobanian HR
PROVIDER: S-EPMC4025675 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Chobanian Harry R HR Guo Yan Y Liu Ping P Chioda Marc M Lanza Thomas J TJ Chang Linda L Kelly Theresa M TM Kan Yanqing Y Palyha Oksana O Guan Xiao-Ming XM Marsh Donald J DJ Metzger Joseph M JM Gorski Judith N JN Raustad Kate K Wang Sheng-Ping SP Strack Alison M AM Miller Randy R Pang Jianmei J Madeira Maria M Lyons Kathy K Dragovic Jasminka J Reitman Marc L ML Nargund Ravi P RP Lin Linus S LS
ACS medicinal chemistry letters 20120121 3
Extensive structure-activity relationship studies of a series derived from atropisomer 1, a previously described chiral benzodiazepine sulfonamide series, led to a potent, brain penetrant and selective compound with excellent preclinical pharmacokinetic across species. We also describe the utilization of a high throughput mouse pharmacodynamic assay which allowed for expedient assessment of pharmacokinetic and brain distribution. ...[more]