Ontology highlight
ABSTRACT:
SUBMITTER: Reitman ML
PROVIDER: S-EPMC5137193 | biostudies-other | 2012 Sep
REPOSITORIES: biostudies-other
Reitman Marc L ML Dishy Victor V Moreau Allison A Denney William S WS Liu Chengcheng C Kraft Walter K WK Mejia Alex V AV Matson Mark A MA Stoch S Aubrey SA Wagner John A JA Lai Eseng E
Journal of clinical pharmacology 20111212 9
MK-5046 is an orally active, potent, selective agonist of the orphan G protein-coupled receptor bombesin receptor subtype-3 (BRS-3) that is under evaluation for treatment of obesity. We report the safety, tolerability, pharmacokinetics, and pharmacodynamics of oral doses of MK-5046 (10-160 mg) in a double-blind, randomized, placebo-controlled study in healthy and obese male volunteers. MK-5046 exposure increased dose proportionally, and MK-5046 was eliminated with an apparent terminal half-life ...[more]